AMH Rapid Quantitative Test (Chemiluminescence Immunoassay)

Application

Anti-Müllerian hormone (AMH), also known as Müllerian inhibiting substance or factor, is a member of the transforming growth factor-β (TGF-β) family. AMH plays an essential role in the regression of Müllerian ducts in the male fetus, which is the initial step in the organogenesis of the male genital tract.

AMH is a homodimeric, disulfide-linked glycoprotein with a molecular weight of 140 kD. It is strongly expressed in Sertoli cells from the onset of testicular differentiation up to puberty, and to a much lesser degree in granulosa cells from birth up to menopause. This expression of AMH is tightly regulated, both spatially and chronologically, ensuring that the gene is expressed only in males during the critical period when the Müllerian ducts are sensitive to its action.

The AMH gene is 275 base pairs (bp) long and is divided into five exons. The 3' part of the fifth exon codes for the bioactive part of the AMH molecule and is extremely GC-rich. This domain is the only region with homology to other members of the TGF-β family.

The AMH gene is located on the short arm of chromosome 19 in humans, specifically in the band 19p13.3.

The tight regulation of AMH expression and its specific role in the regression of Müllerian ducts during male genital tract development highlight the importance of this TGF-β family member in the differentiation and organization of the male reproductive system.

Product Specification

Features

Smart - Photosensitive and Luminescent Microspheres

Rapid - Whole Blood Sample Type Supported & No Centrifuge Needed

Convenient - Room Temperature Storage & Minimal sample consumption

Clinical significance

Assessment of Ovarian Reserve

Prediction of Ovarian Response to Stimulation in Assisted Reproductive Technologies (ART)

Individualization of Fertility Treatment Plans

Prediction of Onset of Menopause

Diagnosis and Management of Polycystic Ovary Syndrome (PCOS)