IL-6 Rapid Quantitative Test (Chemiluminescence Immunoassay) is used for in vitro quantitative detection of the Interleukin-6 (IL-6) concentration in human serum, plasma that contains heparin /EDTA and other anticoagulants and venous whole blood samples, mainly used for auxiliary diagnosis of inflammation diseases.
Application
Interleukin-6 (IL-6) is a pleiotropic cytokine involved in the physiology of virtually every organ system. Recent studies have demonstrated that IL-6 plays a crucial role in regulating the balance between IL-17-producing T helper 17 (Th17) cells and regulatory T (Treg) cells.
These two T-cell subsets play prominent and opposing roles in immune functions. Th17 cells are key players in the pathogenesis of autoimmune diseases and provide protection against certain bacterial infections, while Treg cells function to restrain excessive effector T-cell responses.
IL-6 induces the development of Th17 cells from naïve T cells, in conjunction with transforming growth factor-beta (TGF-β). In contrast, IL-6 inhibits the TGF-β-induced differentiation of Treg cells. This modulation of the Th17/Treg balance by IL-6 is an important mechanism underlying its involvement in both autoimmunity and host defense.
Product Specification
Sample Volume |
WB: 40μL; Serum/Plasma: 20μL |
Test Time |
10 mins |
Measuring Range |
5-5000 pg/mL |
Pack |
20T、40T、100T |
Storage |
2~30℃ |
Features
Smart - Photosensitive and Luminescent Microspheres
Rapid - Whole Blood Sample Type Supported & No Centrifuge Needed
Convenient - Room Temperature Storage & Minimal sample consumption
Clinical significance
Rheumatoid Arthritis and Autoimmune Diseases
Cytokine Release Syndrome (CRS) Assessment
Sepsis and Inflammatory Response
Assessment of Inflammatory Bowel Disease (IBD)
Cardiovascular Risk Assessment
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