HbA1c Rapid Quantitative Test (Chemiluminescence Immunoassay)

Application

HbA1c is a product of the non-enzymatic chemical reaction between glucose and the N-terminus of the hemoglobin protein's β-chain (valine) amino groups. From a molecular biology perspective, HbA1c belongs to a diverse group of molecules termed advanced glycation end-products (AGEs).

In both diabetic and non-diabetic individuals, the relative levels of HbA1c reflect the duration and severity of hyperglycemic episodes, as well as the overall exposure to extracellular glucose present in the circulation. HbA1c levels, at varying cut-offs, have been developed as biomarkers for both the diagnosis of diabetes and the assessment of chronic glycemic control.

HbA1c reflects the average plasma glucose concentration over the previous 8 to 12 weeks. It can be measured at any time of the day and does not require special preparation, such as fasting. These properties have made HbA1c the preferred test for assessing glycemic control in people with diabetes.

More recently, there has been substantial interest in using HbA1c as a diagnostic test for diabetes and as a screening test for individuals at high risk of developing the condition. The use of HbA1c can avoid the problem of day-to-day variability in glucose values and eliminates the need for fasting and preceding dietary preparations. These advantages have important implications for the early identification and treatment of diabetes, which have been strongly advocated in recent years.

A persistently elevated level of HbA1c increases the risk of various vascular complications, such as coronary disease, heart attack, stroke, heart failure, kidney failure, blindness, erectile dysfunction, neuropathy, gangrene, gastroparesis, and short-term complications of surgery, including poor wound healing.

Product Specification

Features

Smart - Photosensitive and Luminescent Microspheres

Rapid - Whole Blood Sample Type Supported & No Centrifuge Needed

Convenient - Room Temperature Storage & Minimal sample consumption

Clinical significance

Diagnosis and Monitoring of Diabetes

Assessment of Long-Term Blood Glucose Control

Cardiovascular Risk Assessment

Medication Adjustment and Treatment Planning

Screening for Prediabetes