WHAT IS IL-6 IL-6 is an immune protein promptly and transiently produced in response to tissue damage and infections. On the other hand, IL-6 is also a pyrogen and is responsible for fever in autoimmune, infectious, or non-infectious diseases. IL-6 is produced in the body, wherever there is inflammation, either acute or chronic. This includes situations such as trauma, burns, cancers, and infection. (Thomas, 2021)   RELATIONSHIP BETWEEN IL-6 AND COVID-19 During the pandemic, scientists have explored the role of IL-6 as a predictor for patients with severe coronavirus disease.   Based on the finding that infection by the severe acute respiratory syndrome-associated coronavirus induces a dose-dependent production of IL-6 from bronchial epithelial cells, a study involving nearly 11,000 patients discovered that treating hospitalized COVID-19 patients with drugs that block the effects of interleukin-6 reduces the risk of death and the need for mechanical ventilation. (Henderson, 2021)   According to the study, in hospitalized patients, administering the interleukin-6 antagonists (such as tocilizumab and sarilumab) in addition to corticosteroids reduces the risk of death by 17%, compared to the use of corticosteroids alone. In patients not on mechanical ventilation, the risk of mechanical ventilation or death is reduced by 21%, compared to the use of corticosteroids alone. (Henderson, 2021)   Some also conducted data analysis of COVID-19 cases at long-term care facilities in Slovakia Patients with hypoxemia had significantly higher concentrations of IL-6, C-reactive protein, procalcitonin, fibrinogen, total bilirubin, aspartate aminotransferase and alanine aminotransferase at initial screening among which IL-6 was identified as the most robust predictor of hypoxemia. (Sabaka et al., 2021)   Given the current situation of global vaccine inequity, people in the lowest income countries will be the ones most at risk of severe and critical COVID-19. Therefore, further work is necessary to clarify the exact role of IL-6 during coronavirus infections and the potential role of this cytokine to be used as a biomarker of viral virulence. Additional work exploring the potential therapeutic use of blocking IL-6 or different products affected by its activity might provide insight into controlling persistent COVID-19 infections. (Velazquez-Salinas et al., 2019)   BIOTIME IL-6 Biotime IL-6 is an in vitro diagnostic test for the quantitative determination of IL 6 in human serum or plasma. As researchers have pointed out a portion of severely ill COVID-19 patients experience rapid deterioration and need for mechanical ventilation due to development of ARDS. Being an unconventional way to address the issue, Biotime IL-6 can also be used to assist in identifying severe inflammatory response in patients with confirmed COVID 19 illness who need mechanical ventilation in conjunction with clinical findings.     References Thomas, L. (2...

14-17, Nov. 2022, the 54th Medica Exhibition will be held in the Dusseldorf Convention Center, Germany. At that time, Biotime's full range of products will be displayed. Medica is recognized as the largest hospital and medical equipment exhibition in the world. With its irreplaceable scale and influence, it ranks first place in the world medical trade exhibition. Every year, nearly 4000 exhibitors from more than 60 countries and regions gather here. On site, new automatic glycated hemoglobin analyzer, HLC-100, and six-channel chemiluminescence analyzer, CLi-1600 will make a wonderful appearance. In addition to the new chemiluminescence platform, the highly praised immunofluorescence platform will also debut. Biotiem immunofluorescence platform has covered multiple series, such as cardiovascular and cerebrovascular, inflammation, hormones, thyroid function, diabetes and kidney injury. The fastest test results can be obtained in 3mins. Biotime aims to meet the needs of different medical institutions and provides users with more comprehensive POCT solutions. It will be a great honor to welcome you to visit Hall 1, Biotime Booth G39-2

Biotime's SARS-CoV-2 Antigen test obtains CE mark for self-testing, the details are as follows: The SARS-CoV-2 Antigen Rapid Qualitative Test that has completed CE certification, this time is another effective tool for the company to actively support global anti-epidemic. It can be operated by individuals who collect the front nasal swab sample by themselves, and the result can be quickly obtained in 20-30 minutes, which is convenient for individuals and families to quickly detect Covid-19, well meets the needs of epidemic prevention and control at home in various countries, and further enriches the Biotime COVID-19 Solution. The company will fully support the cause of global COVID-19 prevention and control, and actively respond to the market demand for testing products in COVID-19.

Immunoglobulin E (IgE) is an antibody produced by the body's immune system in response to a perceived threat. It is one of the five types of immunoglobulins (A, G, M, D, and E) and is usually found in very small amounts in the blood. The total IgE test can be used to help screen and detect allergic diseases. It measures the total amount of immunoglobulin E in the blood. Immunoglobulin is a protein that plays a key role in the human immune system. They are produced by specific immune cells called plasma cells. Immunoglobulins are produced against bacteria, viruses, and other microorganisms and substances that are recognized as "non-self" or provide harmful antigens to the immune system. Elevated concentrations of total immunoglobulin E (IgE) can be found in a variety of clinical diseases, including allergic diseases, certain primary immune deficiencies, infections, inflammatory diseases, and malignant tumors, and to a lesser extent, are related to the immunity of parasites is related. Occasionally, an IgE test may be needed to help diagnose a very rare genetic disease called high immunoglobulin E syndrome (Job syndrome). People with this disease usually have significantly higher IgE levels than normal, and may have eczema, recurrent sinus and lung infections, bone defects, and severe skin infections. A large increase in IgE concentration may indicate that a person has inherited this condition. When a person experiences periodic or persistent symptoms due to an allergic reaction, especially when the underlying allergen is unknown, a total IgE test may be required. Symptoms may include those that indicate involvement of the skin, respiratory system, and/or digestive system, such as: -Periodic or persistent itching -Urticaria -Itchy eyes -Eczema -Nausea, vomiting, persistent diarrhea -Sneezing, coughing, congestion -Difficulty breathing -Asthma symptoms: wheezing, difficulty breathing, coughing, chest tightness Biotime IgE rapid quantitative test kit is in great demand right now. It allows use of different sample material: whole blood, plasma, and serum with results conveniently available, making the process a lot less cumbersome and genuinely helping screen and detect a variety of clinical diseases. Reference 1. Homburger HA: Allergic diseases. In: Clinical Diagnosis and Management by Laboratory Methods. 21st ed. WB Saunders Company. 2007;961-971 2. Martins TB, Bandhauer ME, Bunker AM, Roberts WL, Hill HR: New childhood and adult reference intervals for total IgE. J Allergy Clin Immunol. 2014 Feb;133(2):589-591 3. Bernstein IL, Li JT, Bernstein DI, et al: Allergy diagnostic testing: An updated practice parameter. Ann Allergy Asthma Immunol. 2008 Mar;100(3 Suppl 3):S1-148 4. Ansotegui IJ, Melioli G, Canonica GW, et al: IgE allergy diagnostics and other relevant tests in allergy, a World Allergy Organization position paper. World Allergy Organ J. 2020 Feb;13(2):100080. doi: 10.1016/j.waojou.2019.100080

Big News Day！Biotime SARS-CoV-2 Antigen Rapid Qualitative Test has been recognized by SFDA. Saudi Food and Drug Authority (SFDA) is an independent body for the Kingdom of Saudi Arabia that aims to ensure food and drug safety for the nation.  The Saudi Ministry of Health has given it responsibility for the regulation of pharmaceuticals, and it is an influential organization among states within the region. Biotime SARS-CoV-2 Antigen Rapid Qualitative Test based on colloidal gold immunochromatography method and intend to use as the qualitative detection of nucleocapsid antigens from SARS-CoV-2 in human nasal swabs, throat swabs, and sputum from individuals who are suspected of COVID-19 by their healthcare provider within the first five days of the onset of symptoms. SFDA authoritative certification means that SARS-CoV-2 Antigen Rapid Qualitative Test is available for sale in Saudi Arabia. If you are interested in this product, please contact us.

On March 10, Biotime donated 2 million of the SARS-COV-2 Antigen Rapid Qualitative Test Kits to Hong Kong. The increasing numbers of the Covid-19 in Hong Kong have been a big concern for the Chinese Government and its people. The Chinese Government has given full support to Hong Kong in its fight against the Covid-19. All sectors of the society and Hong Kong compatriots are helping each other and assisting Hong Kong in its fight against the Covid-19 in various ways. As a company that has long supported global anti-epidemic efforts through In Vitro Diagnostics, Biotime has actively responded to support Hong Kong in its fight against the COVID-19. We donated 12-million-yuan worth of epidemic prevention materials to Hong Kong. Biotime's Vice President of Operations, Jim Huang, presided over the donation ceremony. Mr. Huang said that as POCT developers, especially during the epidemic, we have a greater responsibility to share the worries and difficulties of our country and compatriots. Biotime COVID-19 antigen tests have played an outstanding role in the UK's epidemic prevention and controlling of the spread of Covid-19. Witnessing the Hong Kong epidemic increasing rapidly, Biotime hoped to play a significant role in Hong Kong's anti-epidemic efforts and assist Hong Kong to win the epidemic prevention and control the spread as soon as possible. ▲vice GM of Operation, Jim Huang Afterward, Biotime contacted Yi Zhiming, a member of the Hong Kong Legislative Council. Mr. Yi expressed his gratitude to the Xiamen Municipal Government and Biotime. He stated that the SARS-COV-2 Antigen Rapid Qualitative Test Kits, once they arrived, Covid-19 test kits will be delivered to the citizens quickly so that a protective wall can be built against the epidemic and protect the health of the Hong Kong citizens. Mr. Yi also mentioned working together will bring Hong Kong back to its former glory ▲ Connect with the senator of Legislative Council of the Hong Kong Special Administrative Region Yi Zhiming. ▲ Dong Zhonghong, Office of the Government of the Hong Kong Special Administrative Region in Fujian. Since Biotime was founded, it has committed itself actively to undertakings such as education, disaster relief, and fulfilling its social responsibility as a company and as well as a form of love to the world. As a result of the epidemic, Biotime has displayed "China's strength" in the prevention and control of epidemics across the globe. ▲ Donor Ceremony

More than 18 month since the outbreak, COVID 19 is still raging in much of the world. The novel coronavirus has mutated into strains such as the Delta variant which was first detected in India and accounted for 99% of Covid-19 cases in the UK by mid-Jun, according to Public Health England. (The Guardian, 2021) Delta strain is a highly contagious and possibly more severe SARS-CoV-2 virus strain. Delta is spreading 50% faster than Alpha, which was 50% more contagious than the original strain of SARS-CoV-2—making the new variant 75% more contagious than the original. (YaleMedicine, 2021) And like we’re seeing now, Delta is outcompeting everything else and becoming the dominant strain. The symptoms of the Delta variant appear to differ from traditional COVID symptoms, According to data from the United Kingdom, the most common COVID symptoms may have changed from those we traditionally associated with the virus. Those include: Put aside fever and cough which have always been common COVID symptoms, and headache and sore throat which have traditionally presented for some people, a runny nose is now being reported significantly more frequently. Meanwhile, loss of smell, which was originally quite common, now ranks ninth. (Herrero, 2021) Although it's still not clear whether it it's more dangerous, scientists are becoming more confident the Delta variant represents a more transmissible SARS-CoV-2 strain. (Fox, 2021) What’s even more concerning, is that the Delta variant that has caused devastation in countries like India and the UK has now mutated to produce another variant called Delta Plus. (Joi, 2021) While vaccines are rolling out, not all of us are able to receive them as soon as we'd like. And because not all of us are yet fully protected, get tested if you have any symptoms, even if it’s “just a sniffle”, to protect yourself with some added peace of mind as well as others in your community. Through the course of the pandemic, Biotime’s consolidated its commitment to bringing accessible COVID-19 rapid self-testing to the masses. Hence a wide range of covid 19 test kits has been rolled out and made available both nationwide and worldwide. In particular, the BIOTIME SARS-CoV-2 IgG/IgM Rapid Qualitative Test is a lateral flow immunoassay intended for qualitative detection and differentiation of IgM and IgG antibodies to SARS-CoV-2 in human serum, plasma (potassium EDTA), and potassium EDTA venous whole blood. Our rapid antigen covid test kit is also qualified to detect both asymptomatic and symptomatic COVID-19, helping society collectively return to daily life. In addition to that, some scientific researches have purposefully assessed the use of D-dimer, PCT, CRP, IL-6, Ferritin as biomarkers for disease severity and mortality in COVID-19 patients. And the results are rather convincing to suggest they can provide important information on the prognosis of the novel corona virus infection. Below is Biotime’s product specification. Shop now on our websit...

The International Federation of Clinical Chemistry and Laboratory Medicine (IFCC) has recognized the Biotime BIOT-YG-I Fluorescence Immunoassay Analyzer and the fully-automated HLC-100 High-Performance Liquid Chromatography Analyzer for their safety and qualification to detect glycosylated hemoglobin HbA1c on Big-News Day. As far as glycosylated hemoglobin detection is concerned, the IFCC is the most widely used laboratory standard. As a provider of diabetes screening, diagnosis, blood glucose control and efficacy observation tests, Biotime is dedicated to providing clinicians and patients with accurate and effective test results.