Product Introduction
D-Dimer is a fibrin degradation product (or FDP), a small protein fragment present in the blood after a blood clot is degraded by fibrinolysis. D-Dimer doesn’t normally present in human blood plasma, except when the coagulation system has been activated, for instance, because of the presence of thrombosis or disseminated intravascular coagulation. It is regarded as a specific fibrinolytic process marker. D-Dimer concentration is used for suspected thrombotic disorders. While a negative result practically rules out thrombosis, a positive result can indicate thrombosis but does not rule out other potential causes. Its main use, therefore, is to exclude thromboembolic disease where the probability is low. In addition, it is used in the diagnosis of the blood disorder disseminated intravascular coagulation. Myocardial infarction, cerebral infarction, pulmonary embolism, venous thrombosis, surgery, cancer, disseminated intravascular coagulation, infection, and tissue necrosis may lead to elevated concentration of D-Dimer. Increased concentration of D-Dimer may also be observed in elderly and hospitalized patients with abnormal coagulation caused by bacteremia [1-3].
Product Specification
Specimen Types
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WB/Plasma
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Specimen Capacity
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WB:80μL; Plasma:50μL
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Reaction Time
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3 min
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Detection Range
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0.1-10mg/L
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Clinical Significance
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<0.5mg/L: No risk of DVT&PE
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Advantages
√ Equipped with special dropper consumables, the operation is easier and more suitable for clinical use
√ Low sample requirements: whole blood can be processed without centrifugation
Clinical significance
√ For deep vein thrombosis (DVT), pulmonary embolism exclusion, and diffuse intravascular coagulation (DIC) auxiliary diagnosis
√ Monitor thrombolytic therapy
Application
ICU, Respiratory Medicine, Emergency Department, Laboratory
Reference
1. Xing Yu, Min Yao, Xiaobin Wei, Yongqing Wang, Bilan Deng . D plasma D-Dimer in the diagnosis of clinical disease[J] Hainan Medicine, 2012, 23 (6): 129-130.
2. Qianhu Wu. Detection of plasma D-Dimer and its relationship with cardiovascular disease [J]. Labeled Immunoassays and Clinical Medicine, 2000, 7 (1): 32-34.
3. Yuning Chen, Dongya Meng, Xiuju Fang. D-Dimer quantitative detection of lung disease[J] Practical diagnosis and treatment of miscellaneous Ch. 2008, 22 (1): 4-5.
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