Meet Biotime on 19-21 October Asia Health 2022, at Impact Exhibition Center, Bangkok, Thailand! It will bring together more than 400 exhibitors, 2,000 experts and scholars, and 40,000 professional visitors from all over the ASEAN region. Majorly, there will be displays of fluorescent immunoassay analyzers with different channels demonstrating the quantitative concentration of analytes in human blood and urine. As well as new range of chemiluminescence immunoassay analyzers will also debut.

On September 2, the 13th Singapore International Medical Exhibition MEDICAL FAIR ASIA 2022 ended perfectly. As one of the most well-known professional medical exhibitions in Asia, it has attracted thousands of medical industry experts and scholars from all over the world. In this exhibition, six series of products of Xiamen Biotime Biotechnology Co., Ltd. made a wonderful appearance, including immunofluorescence, chemiluminescence, electrochemistry, rapid test, high performance liquid chromatography and molecular diagnosis. With many new products, Biotime's immunofluorescence platform will have more than 50 test items, and the new product single-channel FLI-100 immunofluorescence analyzer had be specially unveiled at this exhibition. CLIA ANALYZER CLi-1600 Lyophilized powder reagent Room temperature storage Homogeneous reaction Chemilumineseent immunoassay There are 3 test instruments of the new chemiluminescence series with different fluxes: single-channel CLi-100, 16-channel CLi-1600 and 20-channel CLi-2000 chemiluminescence analyzers, and will cover 33 test items; 34 Different rapid test items include respiratory infectious diseases, dengue, malaria and COVID-19 solutions. HPLC ANALYZER HLC-100 12 sample positions HbA1c analysis in 2 minutes The gold standard for the detection HbA1c At the same time, we promoted HLC-100 Fully Automated HbA1c Analyzer, Detection Kit For Monkeypox Virus ( Real-Time PCR ), and the electrochemical platform include blood glucose, blood lead, blood ketone and cholesterol detectors. During the exhibition from August 31st to September 2nd, Xiamen Biotime conducted in-depth communication and cooperation with many medical industry experts, university professors, professional agents, etc. from all over the world. In the future, Biotime will continue to uphold the mission of science and technology to serve human health, and continue to help the development of the global health industry with high-quality products and services.

On August 31st, Expo Med Mexico 2022 opened at the Mexico International Convention Center. EXPOMED is Mexico's medical supplies and equipment industry event, where medical industry leaders from around the world gather to exchange experiences and share information. At the exhibition site, Xiamen Biotime Biotechnology Co., Ltd. provided comprehensive medical in vitro diagnosis solutions for experts and distributors from all over the world. Many star products were on display. The immunofluorescence instruments, such as BIO-YG-I, FLI-100, FLI-600, COVID-19 solution and respiratory disease solution, attracted visitors to stop and visit. From August 31 to September 2, we will wait for you at Booth 3631, Mexico City International Convention Center.

On August 31, the 13th Singapore International MEDICAL FAIR ASIA 2022 was held at the Marina Bay Sands Convention Centre. With its comprehensive POCT solutions and newly developed innovative products, Xiamen Biotime Biotechnology Co., Ltd. has made an amazing debut. On the first day of the exhibition, there was an endless stream of customers at the exhibition booth. Many international friends came to learn about the rapid detection products and solutions of Biotime. In this exhibition, Biotime showcased three product series, including immunofluorescence instrument BIOT-YG-I, FLI-100, and FLI-600, HPLC automatic HbA1c analyzer, diabetes diagnostic reagent, monkeypox product, and COVID-19 solution, and introduced customized solutions that meet the needs of each customer which won high praise. From August 30th to September 2nd, we are looking forward to your arrival at booth 2N06, Marina Bay Sands Convention Centre, Singapore!

The human male and female reproductive cycles are controlled by the interaction of hormones from the hypothalamus and anterior pituitary with hormones from reproductive tissues and organs. In both sexes, the hypothalamus monitors and causes the release of hormones from the pituitary gland. When the reproductive hormone is required, the hypothalamus sends a gonadotropin-releasing hormone (GnRH) to the anterior pituitary. This causes the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the anterior pituitary into the blood. Note that the body must reach puberty in order for the adrenals to release the hormones that must be present for GnRH to be produced. Although FSH and LH are named after their functions in female reproduction, they are produced in both sexes and play important roles in controlling reproduction. Male Hormones At the onset of puberty, the hypothalamus causes the release of FSH and LH into the male system for the first time. FSH enters the testes and stimulates the Sertoli cells to begin facilitating spermatogenesis. LH also enters the testes and stimulates the interstitial cells of Leydig to make and release testosterone into the testes and the blood. Testosterone, the hormone responsible for the secondary sexual characteristics that develop in the male during adolescence, stimulates spermatogenesis. These secondary sex characteristics include a deepening of the voice, the growth of facial, axillary, and pubic hair, and the beginnings of the sex drive. Figure 1 Hormones control sperm production. Female Hormones The control of reproduction in females is more complex. As with the male, the anterior pituitary hormones cause the release of the hormones FSH and LH. In addition, estrogens and progesterone are released from the developing follicles. Estrogen is the reproductive hormone in females that assists in endometrial regrowth, ovulation, and calcium absorption. These include breast development. Progesterone assists in endometrial re-growth and inhibition of FSH and LH release. In females, FSH stimulates development of egg cells, called ova, which develop in structures called follicles. Follicle cells produce the hormone inhibin, which inhibits FSH production. LH also plays a role in the development of ova, induction of ovulation, and stimulation of estradiol and progesterone production by the ovaries. Estradiol and progesterone are steroid hormones that prepare the body for pregnancy. Estradiol produces secondary sex characteristics in females, while both estradiol and progesterone regulate the menstrual cycle. The Ovarian Cycle and the Menstrual Cycle The ovarian cycle governs the preparation of endocrine tissues and release of eggs, while the menstrual cycle governs the preparation and maintenance of the uterine lining. These cycles occur concurrently and are coordinated over a 22–32 day cycle, with an average...

On July 26, the 74th AACC ANNUAL SCIENTIFIC MEETING CLINICAL LAB EXPO kicked off at the McCormick Convention Center in Chicago, USA! More than 800 companies from more than 100 countries around the world, tens of thousands of international medical professionals and healthcare practitioners came to participate in the exhibition.         ▲ Exhibition site Xiamen Biotime Biotechnology Co., Ltd. made a wonderful appearance with star products and multi-scene solutions, which attracted widespread attention.         ▲ LIVE connection 7.26 - 7.29, 2022 The exhibition is in full swing We are looking forward to your arrival at booth 542

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What is Chemiluminescent Immunoassay Chemiluminescent immunoassay (CLIA) is an immunoassay technique where the label, i.e. the true “indicator” of the analytic reaction, is a luminescent molecule. In general, luminescence is the emission of visible or near-visible radiation which is generated when an electron transition from an excited state to a ground state. The resultant potential energy in the atom gets released in the form of light. (Cinquanta, Fontana and Bizzaro, 2017) Chemiluminescent immunoassays offer one of the best solutions for the quantification of low concentrations of specific analytes from a complex mixture for in vitro diagnostic industry. They can also be used as diagnostic tools in medicine, as well as being used in several other different industries for various applications. (Lorne Laboratories, 2021) How Does Chemiluminescence Work Chemiluminescence immunoassay (CLIA) is an assay that combines the chemiluminescence techniques with immunochemical reactions. The assay format is similar to enzyme-linked immunoassays, usually based on heterogeneous assays where antibodies or antigens are immobilized on a solid phase but one of the components is conjugated with a chemiluminescent label. (Lorne Laboratories, 2021) (BrightTALK, 2021) CLIA utilizes chemical probes which could generate light emission through a chemical reactions to label the antibody. (Creative-diagnostics, 2021) The Benefits of Chemiluminescence Immunoassay In recent years, CLIA has gained increasing attention in different fields, including life science, clinical diagnosis, environmental monitoring, food safety, and pharmaceutical analysis because there are benefits of using chemiluminescence such as: ultra-sensitive good specificity wide range of applications simple equipment wide linear range easier in operation and design can detect small amounts of the biological molecule does not require long incubations and the addition of stopping reagents (Creative-diagnostics, 2021) Key Types of Chemiluminescent Immunoassay Methods Chemiluminescent methods that have been commonly seen are direct - using luminophore markers, indirect—using enzyme markers, or electrogenerated – typically nanomaterials based. (Cinquanta, Fontana and Bizzaro, 2017) (Ju, Lai and Yan, 2017) Indirect CLIA, using enzyme markers This common CLIA method involves an enzyme, typically horseradish peroxidase (HRP) or alkaline phosphatase (AP), conjugated to a secondary antibody. This HRP– or AP–secondary antibody complex then catalyzes the conversion of chemiluminescent substrate, luminol and CSPD reagent respectively. These substrates, when oxidized, provide an easy means of signal detection and quantification due to prolonged signal emission. (Shimadzu, 2021) Direct CLIA, using luminophore markers This method commonly uses acridinium esters as luminophores conjugated directly to the primary monoclonal antibody to generate a signal. Acridinium esters are highly specific labels that spontaneously oxidiz...