ASO Rapid Quantitative Test (Fluorescence Immunoassay)

The Biotime ASO Rapid Quantitative Test is intended to quantify the concentration of ASO in human serum, plasma and whole blood onBiotime FIA Analyzer by fluorescent immunoassay. The test is used as an aid detection of auxiliary diagnosis of acute rheumatic fever.

-Fluorescence immunoassay

-Auxiliary diagnosis of acute rheumatic fever

For in vitro diagnostic use only. For professional use only.

Specification

Clinical Significance:

Confirms recent Group A Streptococcus (GAS) infection

Aids diagnosis of post-streptococcal complications:

Acute Rheumatic Fever (ARF)

Post-streptococcal glomerulonephritis

Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal Infections (PANDAS)

Key Points:

Antibodies rise 1–3 weeks post-infection, peak at 3–5 weeks, and decline over 6–12 months

Positive in only 80–85% of GAS infections → negative result does not rule out infection

Serial rising titers (paired samples 10–28 days apart) provide stronger evidence than a single measurement

Upper limit of normal varies by age, region, and population (e.g., children: up to 515 IU/mL in some studies)

Combined with anti-DNase B increases sensitivity to ~95% for detecting prior GAS infection